Abstract
Although some articles portray coffee as negative, most evidence points toward a direct association between coffee intake and human health. This chapter describes the composition of coffee and the protective properties associated with various liver diseases. The main active components of coffee are caffeine, chlorogenic acid, diterpenes (cafestol and kahweol), trigonelline, melanoidins, and nicotinic acid. Antifibrotic properties are well documented and are associated with downregulation of transforming growth factor, connective tissue growth factor, and antioxidant effects; anticarcinogenic properties are caused in part by proapoptotic and antioxidant actions; coffee also inhibits the propagation of hepatitis C virus. There is not enough evidence to recommend coffee as a medicine to “treat” patients with liver disease; however, moderate daily coffee use is a reasonable adjuvant to therapy for these diseases.
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