Abstract
restriction increased expression of NR2A and NR2B proteins and decreased expression of p-CREB and BDNF proteins in the Hp were observed. The up-regulation of NR2A protein accompanied by a decreased expression of p-CREB and BDNF proteins was also found in the PFC, but only after prolonged (6 weeks) zinc deprivation. Conclusions: The current data show that the increased expression of hippocampal NR2A and NR2B proteins after dietary zinc deprivation is linked to the depressive-like behavior. The altered composition of NMDAR subunits has been observed in experimental models of depression based on stress exposure [2] and in post-mortem tissues of suicide victims who may have suffered from depression [3]. The present data further support the zinc deficiency paradigm as a model of depression. Moreover, it indicates that changes of NMDAR subunits at the protein level in a response to zinc deprivation are complex and vary across brain regions and the course of time.
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