P.1.f.005 Genetic risk factors for cytokine-induced depression

Abstract

with haloperidol, patients of group 2 (n = 15) received maintenance therapy with atypical antipsychotic olanzapine (Zyprexa, Eli Lilly). Criteria of psychopathological symptoms according to psychometric scale PANSS, sex, age, length of disease in patients of both groups at admission to hospital were met. Immunological examination included identification of phenotypes of surface receptors of immunocompetent cells, levels of immunoglobulins IgM, IgG, IgA, circulating immune complexes (CIC), serum levels of cortisol, aspartate and alanine aminotransferase. Results: In patients under maintenance therapy with typical neuroleptics, quantitative deficit of parameters of cellular immunity with reliable, as compared with reference range, decrease of T-lymphocytes CD2+-, CD3+(p = 0.0001 in both cases), T-helpers-inductors CD4+(p = 0.007), natural killers CD16+(p = 0.0001), decrease of phagocytic activity of neutrophils (p = 0.023) was identified. High level of circulating immune complexes (p = 0.0001), number of lymphocytes with receptors of readiness to apoptosis CD95 (p = 0.0001), lymphocytes with markers of delayed activation of HLADR (p = 0.001) was revealed. In patients under long-term therapy with olanzapine, less severe suppression of parameters of cellular immunity has been revealed: higher (comparable with reference range) relative values of number of T-lymphocytes of CD2+and T-helpers-inductors CD4+(p = 0.001 between groups in both cases), lower level of CIC (p = 0.0001 between groups). High level of aspartate aminotransferase and alanine aminotransferase (in both cases) has been noted in patients of group 1 (p = 0.0001). The lower level of aspartate aminotransferase was typical for patients of group 2 as compared both with patients of group 1, and with reference values of norm (p = 0.008 and p = 0.015, respectively). Increase of level of the cortisol, revealed in all examined persons (p = 0.0001 as compared with reference norm), was more significant in patients of group 2 (p = 0.019 between groups). Conclusions: Thus, it has been identified that acute period of schizophrenia after long-term antipsychotic maintenance therapy with classical neuroleptics is characterized by more severe disturbances of immune and biochemical parameters of patients as compared with exacerbation of disease after long-term maintenance therapy with olanzapine.