P.1.d.017 Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats

Abstract

Theoretical models of injurious animal contests, such as the cumulative assessment model (CAM), predict that an individual's decision to give up and retreat from a fight is determined by reaching a maximum cost threshold (Cmax). Under this model, an individual gives up when the accumulated costs of persisting exceed this threshold. CAM predicts that the velocity with which Cmax is reached depends on both the energetic (physiological) costs of remaining in the fight and the damage costs of injuries received. Here we propose that damage costs are accumulated not only by receiving injuries, but in some cases also by inflicting injury (attacking). We argue that these self-inflicted damage costs need to be incorporated into theoretical frameworks to fully understand what drives an individual to make the decision to give up, and we call for further research into this area.