Abstract
The notion of mega doses of ascorbic acid (vitamin C) for cancer treatment has recently been revived. Besides animal experimentation, evidence from cellular and molecular research suggests a combined oxidative and metabolic mechanism behind the specific cytotoxicity of vitamin C towards cancerous cells. Here we investigate the efficacy of vitamin C against breast cancer cell lines. This work showcases a distinctive metabolic shift induced by ascorbate across multiple cell lines, disruption in the RedOx homeostasis, and the consequent cytotoxic effects. To further define the source of ascorbate's toxicity we probed the potential uptake routs of both ascorbic acid and dehydroascorbate (the oxidized form of ascorbic acid) and the extra and intra cellular ROS resulting from ascorbate treatment.
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