Abstract
In 145 CRCs, by multivariate correspondence analysis, we found an association between Vangl2 methylation and BRAF mutation (p=0.0001), functional p53 (p<0.0001), and low IHC expression of hMLH1 (p=0.0141), Cox-2 (p=0.002), E-cadherin (p=0.0019) and cytoplasmic β-catenin (p=0.0019). No association was found with KRAS mutation. Conclusions: Epigenetic loss of Vangl2 occurs in MSI CRC and is associated with other molecular features of this subset of tumors. The association with BRAF mutation suggests that Vangl2 methylation might contribute to Wnt derangement in sporadic MSI CRC.
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