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Abstract
p< 0.05). I.c.v. administration of IL-1b significantly disrupted PPI at the lowest dose only (0.5 ng). Conclusion: Present results support the hypothesis that IL-1b and KYNA are important players in the pathophysiology of psychotic diseases, such as schizophrenia and bipolar disorder. Notably, only administration of the lowest dose IL-1b had a PPI disruptive effect, indicating that this effect may be mediated by the increased brain KYNA concentrations observed at this dose. Present data are also in line with recent in-vitro data from our laboratory showing that IL-1b, by induction of tryptophan 2,3-dioxygenase, increase KYNA production in human cortical astrocytes.
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