P.085 The effect of remote ischemic conditioning on cognitive and radiological outcomes in cerebrovascular diseases: a systematic review

Abstract

Background: The effect of remote ischemic conditioning on cognitive and radiological outcomes in patients with cerebrovascular disease is uncertain. We performed a systematic review to evaluate the effects of remote ischemic conditioning on cognitive and radiological outcomes in patients with cerebrovascular diseases. Methods: A systematic search using relevant keywords and database specific terms was conducted in MEDLINE, Embase, and Web of Science from inception to October 27 2022. Results: A total of 4269 articles were screened, of which 20 were included. Ten papers assessing cognitive outcomes were included, with 5/10 reporting improvements in cognitive scores relative to a control group. Sixteen papers reporting on radiologic outcomes were included, three reporting on changes in infarct volume, and four on lesion volume. Improvement in infarct and lesion volume was reported in 1/3 studies and 4/4 studies respectively, however there was considerable variation in the time between assessments (range 1-365 days). Nine papers assessing blood flow changes were found, of which 3/8 using transcranial doppler reported improved blood flow velocity post intervention. Conclusions: The articles identified suggest that remote ischemic conditioning may provide improvement for both cognitive and radiological outcomes in patients with cerebrovascular diseases, however future well-designed studies are needed to determine degree of benefit.