P-084: INFECTIOUS PROFILE OF SICKLE CELL PATIENTS IN THE HEMATOLOGY DEPARTMENTS OF CONAKRY UNIVERSITY HOSPITAL

Abstract

Purpose: Infection a factor triggering sickle cell crises, a frequent cause of hospitalization as well as a factor of poor prognosis in sickle cell patients. The objective is to contribute to improving the management of sickle cell disease in Guinea by determining their infectious profile. Materials and methods: This was a descriptive and analytical prospective study lasting 08 months from September 01 to April 30, 2021 carried out at the University Hospital of Conakry. We included in this study all patients hospitalized for sickle cell disease in our departments with an infectious syndrome, who had carried out the infectious assessment. Results: out of 68 sickle cell patients included, 62 had an infection, i.e. 91.17%, mean patient age was 26.17±11.97 years,the female sex wasslightlyrepresented i.e. 51.61%,and a female to male sex ratio of 1.06. The most common reasons for consultation were osteo-articular pain 96.77% followed by fever 95.16%. The most common type of infection in our study was parasitic 93.55%, followed by bacterial 30.65%. The germs found were: Escherichia coli (68.75%), Salmonella typhi (31.25%), staphylococcus (50.00%), Koch bacillus 0.14%, candida albicans (66.66%) Plasmodium (87.10 %), Ascaris Eggs (46.15%), Amoeba Cyst (23.07%), Hookworm (11.54%), HBV (7.01%), HIV (5.26%), Taénia (7.69%), Gardenerella vaginalis (33.33%) and Neisseria Gonorhée (25.00%). The management of infections was made according to the etiology found: antiparasitics (Artesunate, Artemether/Lumefantrine, Albendazole, praziquantel), antibiotics (Ceftriaxone‚ metronidazole, amoxicillin-clavulanic acid, ciprofloxacin), antifungals (Nystatin, Fluconazole, Miconazole and antiretrovirals (Emtricitabine, Lamuvidine and Tenofovir).evolution after treatment was favorable in88.71% of cases and we noted 4.48% transfer, 3.23% discharge against medical advice and 3.23% death. Conclusion: Infection is a common cause of hospitalization in sickle cell patients. Bone and joint pain and Fever were the most frequent clinical presentations, the types of infections were bacterial, parasitic, viral and fungal. The treatment of infections was made of antibacterials, antiparasitics, antivirals and antifungals. The authors do not declare any conflict of interest