P-03-5 Giant Vulvar Condyloma Acuminata Treated Successfully With Intralesional Tuberculin Purified Protein Derivative: A Case Report

Abstract

Giant condylomata acuminata (Buschke-Löwenstein tumor), represents a rare, sexually transmitted disease, usually resulting from infection with human papillomavirus (HPV) types 6 and 11. It is a challenging condition which is difficult to manage with both surgical and medical methods. The purpose of this article was to stress the importance of immunotherapy in treating such cases without disrupting the normal anatomy. The case was a 20 years old married female patient presented with a 14 cm x 10 cm exophytic mass of the vulva in addition to smaller masses extending to the internal vaginal wall and perineum for 4 months duration. Biopsy confirmed that it was a giant condyloma accuminata without evidence of cytological atypia or malignancy. Workup included a pap smear, human immunodeficiency virus (HIV) serology and pelvic magnetic resonance imaging and all were negative. The lesions were treated successfully with 6 sessions of intralesional immunotherapy with tuberculin purified protein derivative (PPD) vaccine. Complete resolution of lesions was obtained after 3 months and there was no recurrence after 1 year of follow-up. By the end of the sessions the patient had a successful sexual intercourse and her quality of life had been improved.