P-029 Severity of Inflammatory Bowel Disease Hospitalizations Varies According to Age and Gender

Abstract

Hospitalizations for Inflammatory Bowel Disease (IBD) are frequent and vary in severity. We aimed to examine differences in the severity of IBD hospitalizations in relationship to age and gender. This was a retrospective cohort study reviewing the 2012 National Inpatient Sample (NIS) database in hospitalizations with a primary ICD-9-CM discharge diagnosis code of either Crohn’s Disease (CD, 555.x) or Ulcerative Colitis (UC, 556.x). Hospitalizations with a secondary diagnosis of CD or UC were also included if they had a primary diagnosis of a disease complication. Elective admissions and those with both a diagnosis of CD and UC were excluded. Our main severity measures included disease behavior (penetrating or obstructing), anemia, malnutrition, Clostridium difficile infection, surgery, length of stay (LOS), mortality and previously defined severity risk scores. Adjusted odds ratios (aOR) and 95% confidence intervals were calculated by comparing 1 demographic group against all others while adjusting for age, gender, region and major co-morbidities including diabetes, obesity, heart, lung, liver and kidney disease. From over 36 million weighted hospitalizations in the United States in 2012, we identified 68,790 hospitalizations for CD and 41,220 for UC. In both CD and UC, those 18-44 years old, males and those in New England were most likely to be hospitalized with IBD than any other demographic (Table 1). Anemia was most likely in males ≥85 and in females 18-44 (Tables 2 and 3). Clostridium difficile infection was most likely in patients <18. Surgery in patients with CD was most likely in male patients ≥85 and female patients <18. Surgery in patients with UC was most likely in male patients 45-64 and female patients <18. Female patients had longer LOS in younger patients, while male patients had longer LOS in older patients. Penetrating CD was most likely in patients 18-44 while obstructing disease was most likely in older patients. Older patients had the highest disease severity scores in CD patients, while younger patients had the highest scores in UC patients. Inflammatory Bowel Disease hospitalization severity varies with the age and gender of the patient. Patients 18–44 years old, males and those in New England were the most likely to be hospitalized with IBD. Females were more likely to have surgery and longer LOS at younger ages when compared to males for both CD and UC. Younger patients were more likely to have penetrating CD and higher disease severity scores in UC than older patients. Older patients were more likely to have obstructing CD and higher disease activity scores in CD patients than younger patients.