P-0229 Characteristics and Outecome of Young Patients with Colorectal Cancer

Abstract

ABSTRACT Introduction Colorectal cancer is predominantly a disease of the elderly population, but this disease is unusual in patients 45 years of age or under, and controversy persists as to prognosis in this subset of patients. The aim of this study was to determine the clinicopathologic features and their impact on patient's prognosis of colorectal cancer in patients aged 45 years or younger. Methods It is a retrospective study conducted at the department of medical oncology of Hassan II University hospital. It included 92 patients younger than 45 years treated for colorectal cancer between January 2007 and January 2012. Results 92 cases of colorectal cancer occurring before the age of 45 years old were noted. It represents 30% of all colorectal cancers collected during the period of study. The tumour was rectal in 58 % and colic in 42 %. The predisposing antecedents of colorectal carcinoma were noted among 12 % of the cases. The clinical symptomatology was dominated by rectal bleeding and abdominal pain. Tomor markers were elevated in 52% of cases. 16% of patients were operated for abdominal occlusion, and 6.5 % for perforation. The cancers were poorly differentiated in 37 % of the cases, 19 % had cell carcinoma signet ring, 10 % had mucosal colloid carcinoma 6.5 % had mucinous Adenocarcinoma, 2 cases of neuroendocrine carcinoma and one case of anal melanoma and were noted. Tumors were presented at advanced stages III and IV in 76% of cases. For patients with R0 resection, 16% had recurred. For metastatic patients, after a first line of chemotherapy, 30% had stable disease, 25% had a partial response. The median survival was 13 months. Conclusion Colorectal cancer in young patients has a poor prognosis with more undifferentiated tumors, advanced stages, complications and recurrences. It requires an early and multidisciplinary care.