P-02-21 Cold-Sensitive Thermo TRP-Channels as Possible Target in Treatment of Premature Ejaculation: Pilot Study

Abstract

To verify the hypothesis that activation of cold-sensitive thermo TRP-channels (csTRPc) in skin of glans penis and foreskin should improve patient control over ejaculation. 33 patients with lifelong premature ejaculation (LPE) (according to ISSM evidence-based updated definition) aged 21-33 years and in stable sexual relationships (duration not less then 6 month) were included. Experimental treatment: small amount of the gel, containing 10% of csTRPc activator TRPaZS-1 should be applied to the glans penis and foreskin 1 hour before sexual intercourse (SI). Treatment period supposed to last 1 month. For this period each patient should have not less than 4 attempts of SI. All parameters of male sexual function (libido, erection, ejaculation (duration of preejaculatory interval, control over ejaculation), orgasm) as well distress, associated with PE, were assessed by means of visual analog scale (0-10) intuitively clear for a patient. Information as to character and duration of sensations after gel application were also collected. Data distribution was described with Me (percentiles25, 75). Statistical significance of differences were assessed with Wiilcoxon test. Significance level 0,05.