Abstract
Introduction: The subject of sequencing chemotherapy, radiotherapy and surgery in locally advanced esophageal cancer (T2, T3 and T4a with any N) is rapidly evolving. As yet there is no consensus regarding the best modality of preoperative therapy. Preoperative chemoradiation followed by reassessment for surgery is an acceptable option. The study aims to explore the impact of pre-surgery treatment intensification by adding induction chemotherapy prior to concomitant chemoradiotherapy on surgical respectability and also to explore the benefit of IMRT as the modality of radiotherapy to minimize radiation dose to lungs and heart to find any possible advantage in lowering surgical morbidity.
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