P-0124 Outcome of Gastric Lymphoma in Elderly Patients with Reduced dose Chemotherapy Followed by Involved Field Radiotherapy

Abstract

ABSTRACT Introduction NHL arises often in extra nodal tissues. Gastrointestinal lymphoma represents the largest group of extra nodal lymphoma. It accounts for approximately 40 percent of them. The most frequent type of non-Hodgkin's lymphoma is diffuse large-B-cell lymphoma. More than half of patients with diffuse large-B-cell lymphoma are over 60 years of age and the treatment of these elderly patients is a difficult challenge. Methods this study included 18 patients from 2008 to 2010 of age more than 60 years. All patients were subjected to six cycles of RCHOP followed by involved field radiotherapy. Radiation (45Gy/25#/5weeks) was given with linear accelerator (energies used 6, 15 MV) by 3DCRT technique. With Keeping in mind the toxicities associated with these drugs and the KPS of the patient, drug dosage was reduced. In most cases it was reduced by 20-25%. Results The completion rate of patients with this regimen was 100%. 5 year local control rate was 96%. Five year disease free survival was 74%. Grade III neurotoxicity was seen in one patient. Conclusion The concept of chemotherapy with reduced dosage followed by involved field radiotherapy is safe and effective in managing the Gastric lymphomas even in patients with associated geriatric co morbidities.