P-0054 - The Change of Serum HER2 Extra Cellular Domain Concentration Before and After Resection in Operable Gastric Cancer Patients in Japan; Consider Relations with Pathological HER2 Status by IHC and Fish

Abstract

Introduction: HER2 extra cellular domain (ECD) can be detected in the serum of healthy person, these concentrations are raised in the patients with cancer; this is dependent on tumor HER2 status and tumor burden. In previous reports, serum HER2-ECD status is useful for judgement of efficacy of anti-HER2 therapy in patients with HER2-positive breast cancer. Although, similarly to breast cancer, approximately 20% gastric cancer show HER2 amplification or overexpression and the efficacy of trastuzumab has been reported, we don't have enough date for serum HER2-ECD of gastric cancer patients.