Abstract
Several antineoplastic treatments disturb wound repair and may even contribute to bone necrosis development. The present study aims to report a case of osteoradionecrosis in the mandible, and how its sequels were controlled by ozonotherapy. A 73-year-old female patient with a history of infiltrative ductal breast carcinoma with mandibular metastasis underwent chemotherapy and radiotherapy in head and neck region. Three years later, she was diagnosed with right hemimandibular osteoradionecrosis that exhibited communication with buccal cavity presenting as a chronic, suppurative, and persistent infection. Adjuvant therapy with ozone was applied through the cutaneous fistula and the exposed necrotic bone. Additionally, nonvital bone debridement was performed. The patient is nonsymptomatic after 1-year follow-up. It is proposed that ozone therapy, due to its antibacterial and immunoregulatory mechanism of action, was an important therapeutic agent for improving the patient's quality of life. Several antineoplastic treatments disturb wound repair and may even contribute to bone necrosis development. The present study aims to report a case of osteoradionecrosis in the mandible, and how its sequels were controlled by ozonotherapy. A 73-year-old female patient with a history of infiltrative ductal breast carcinoma with mandibular metastasis underwent chemotherapy and radiotherapy in head and neck region. Three years later, she was diagnosed with right hemimandibular osteoradionecrosis that exhibited communication with buccal cavity presenting as a chronic, suppurative, and persistent infection. Adjuvant therapy with ozone was applied through the cutaneous fistula and the exposed necrotic bone. Additionally, nonvital bone debridement was performed. The patient is nonsymptomatic after 1-year follow-up. It is proposed that ozone therapy, due to its antibacterial and immunoregulatory mechanism of action, was an important therapeutic agent for improving the patient's quality of life.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
