Abstract
The aim was to demonstrate the available evidence on ozone therapy in patients with COVID-19 and its therapeutic applicability through hospital protocols. This is an integrative review, carried out in PubMed and LILACS search sources, from 2011 to 2021. 87 articles were identified, but 11 articles were selected that suited the studied theme. The literature studied indicated that ozone exerts antiviral activity by inhibiting viral replication and direct inactivation of viruses. It is also an adjuvant to antiviral drugs. Combined treatment with ozone and antivirals has been shown to reduce inflammation and lung damage. The routes of ozone administration were systemic (rectal) and autohemotherapy. Conclusions: Ozone therapy is an adjuvant therapy to antiviral treatment in COVID-19-positive patients, in addition to being economically viable and easy to administer.
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