Ozone Degradation of Iodinated Pharmaceutical Compounds

Abstract

This study investigates the aqueous degradation of four iodinated x-ray contrast media (ICM) compounds (diatrizoate, iomeprol, iopromide, and iopamidol) by ozone and combined ozone and hydrogen peroxide. In laboratory scale experiments, second-order kinetic rate constants for the reactions of the ICM compounds with molecular ozone and hydroxyl radicals, and overall at pH 7.5, were determined. For the four ICM compounds the degradation rate constants with molecular ozone were low and in the range of 1–20 M−1 s−1 , whereas the rate constants with hydroxyl radicals were in the range of 1× 109 –3× 109 M−1 s−1 . Diatrizoate had the lowest rate constant of the four compounds with respect to molecular ozone reactions. At pH 7.5, the extent of compound degradation was proportional to the applied ozone dose and inversely related to the initial compound concentration at a given ozone dose. At this pH approximately 90% of the degradation could be attributed to hydroxyl radical reactions. Enhancement of the radical m...