Abstract
Drugs for inflammatory bowel diseases can be associated with serious side effects, and the development of alternative candidate resources derived from natural products has attracted considerable attention. Oyster extract (OE) derived from Crassostrea gigas contains glycogen, taurine, and amino acids, and has been assigned diverse health-promoting properties. This study investigated the anti-colitis effect of OE intake on fecal microbiota and its metabolites of acute experimental colitis mouse model induced by dextran sulfate sodium (DSS). C57BL/6J mice (male) were divided into three groups: (1) American Institute of Nutrition (AIN) 93G diet + DSS-untreated, (2) AIN93G diet + DSS-treated, and (3) 5% OE diet + DSS-treated. Mice were fed each diet for 21 days, and then administered 2.5% DSS solution to induce acute colitis for 7 days. In DSS-induced colitis mice, OE decreased body weight loss and increased disease activity index during the DSS-induced period. In addition, OE tended to decrease the colon length shortening and the relative spleen weight and alleviated colonic tissue damage. Moreover, OE improved fecal short-chain fatty acids compositions and altered the structure of fecal microbiota. These results provide insight into the health-promoting property of OE in alleviating DSS-induced acute colitis, providing a basis for the development and use of functional foods.
Highlights
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders characterized by chronic epithelial damage and relapsing/remitting inflammation of the colon [1]
Algal oil [8], propolis extract [9], peptides derived from tuna [10], taurine [11], and astragalin [12] have been reported to exert protective effects against experimental colitis induced by dextran sulfate sodium (DSS) in mice
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Summary
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders characterized by chronic epithelial damage and relapsing/remitting inflammation of the colon [1]. Natural products have been attracting attention as alternatives to drugs and are being explored as alternative treatments to enhance conventional IBD therapy [6] These alternative therapies are of great interest because of their low side effects [7]. We have previously reported that OE intake alters the composition of gut microbiota and its metabolites including short-chain fatty acids (SCFA) in mice and rats [20,21]. Few studies have focused on the anti-colitis effects of dietary OE on DSS-induced acute experimental colitis in mice. We investigated the anti-colitis effect of OE intake related to gut microbiota and its metabolites in a DSS-induced acute experimental colitis mouse model
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