Oxytocin treatment in pediatric populations.

Adrienne E Taylor,Hsu-En Lee,Femke T A Buisman-Pijlman

doi:10.3389/fnbeh.2014.00360

Adrienne E Taylor, Hsu-En Lee + Show 1 more

Open Access

https://doi.org/10.3389/fnbeh.2014.00360

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Abstract

The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is well-recognized. Moreover, the use of oxytocin as a facilitator of social and other behaviors is becoming more and more accepted. Many positive effects have been attributed to intranasal oxytocin administration in animals and humans; with current research highlighting encouraging advances in its potential for use in mental health disorders. The new frontier will be investigating the effective use of oxytocin in pediatric populations. Limited animal data is available on this. Large-scale human studies focusing on autism are currently under way, but many other possibilities seem to lie in the future. However, we need to know more about the risks and effects of repeated use on the developing brain and body. This paper will provide an overview of the current understanding of the role of endogenous oxytocin and its related neuropeptide systems in influencing behaviors, in particular attachment, and will review (a) the literature on the use of intranasal oxytocin in young animals, children (age range birth-12 years) and adolescents (age range 13–19 years), (b) the expected benefits and risks based on the current research, and (c) the risks of oxytocin in children with severe psychopathology and early life trauma. The paper will conclude with a clinical perspective on these findings.

Highlights

Oxytocin treatment in pediatric populationsReviewed by: Valery Grinevich, German Cancer Research Center DKFZ and University of Heidelberg, Germany Bernadette Von Dawans, University of Freiburg, Germany
Current understanding of oxytocin and its related neuropeptide systems is growing at an exponential rate
An evolving wealth of animal and human data relating to the neuro-modulatory role of the endogenous oxytocin system, its interactions with other neural pathways, and its implications on behaviors from a neuroscience perspective is expanding at an exponential rate (Tops et al, 2014)

Summary

Oxytocin treatment in pediatric populations

Reviewed by: Valery Grinevich, German Cancer Research Center DKFZ and University of Heidelberg, Germany Bernadette Von Dawans, University of Freiburg, Germany. The role of endogenous oxytocin as neuromodulator of birth, lactation and social behaviors is well-recognized. The use of oxytocin as a facilitator of social and other behaviors is becoming more and more accepted. Many positive effects have been attributed to intranasal oxytocin administration in animals and humans; with current research highlighting encouraging advances in its potential for use in mental health disorders. This paper will provide an overview of the current understanding of the role of endogenous oxytocin and its related neuropeptide systems in influencing behaviors, in particular attachment, and will review (a) the literature on the use of intranasal oxytocin in young animals, children (age range birth-12 years) and adolescents (age range 13–19 years), (b) the expected benefits and risks based on the current research, and (c) the risks of oxytocin in children with severe psychopathology and early life trauma.

INTRODUCTION

Dose of OXT and route of administration

Different effects on social and anxiety behavior in the sexes

Clinical outcome

Findings

DISCUSSION