Oxytocin has sex-specific effects on trust and underlying neurophysiological processes

Abstract

The neuropeptide oxytocin (OT) regulates mammalian social approach behavior across sexes. Yet most OT studies in humans exclusively investigated men. Here, we studied sex differences in OT’s effects on human trust behavior in 144 heterosexual participants (73 women, 71 men). Participants received 24 international units of intranasal OT or placebo treatment and played a trust game in the role of the investor while undergoing electroencephalography. Trustees were represented by photos of the other sex gradually varying in their pre-rated intensities of facial features signaling attractiveness and threat. On a behavioral level, we observed that OT increased trust in men and reduced it in women when trustees showed weak signals of attractiveness and threat. Correspondingly, on the neurophysiological level, we noted that OT intensified the P100 in male participants, but dampened it in female ones. Our findings demonstrate OT’s sex- and context-specific effects on social approach behavior and an underlying early visual attention-related brain process. This evidence demonstrates the need to consider psychobiological mechanisms of sexual dimorphism in human OT research.