Abstract
In the present study we have investigated the effect ot oxytocin on the production of prostagianndins E and F (PGE and PGF) by human decidua, amnion, and myomatrium in vitro. We found that oxytocin causes a signfftcant increase in the proction of both PGE and PGF in the decidua and in the production of PGE in the amnion. In the myometrium the stimulatory effect of oxytocin on PGF production was small and not statistically significant, and PGE production was not affected at all. On that basis of these results, we process that oxytocin provides the stimulus for the accelerated prostaglandin production in decidua and fetal membranes at the onset of labor. Since oxytocin levels rise in the fetal circulation at this time, the oxytocin stimulus may be of fetal origin as well as of maternal origin. (Am. J. Obstet. Gynecol. 141:694,1981.)
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