Oxytocin and Interleukin-14: New suggested indicators for prediction of type 2 diabetes-induced nephropathy

Abstract

Diabetes is one of the major risk factors for chronic renal failure (CRF). The present work involved studying the effect of lifestyle factors such as (age, gender, smoking and area of residence) which can affect chronic renal diseases. Also, the study estimated Oxytocin (Oxt) and Interleukin-14 (IL-14) using the sandwich ELISA technique in the serum of type 2 diabetic patients with CRF who presented to hemodialysis and a control group. Blood samples of (50) diagnosed type 2 diabetic patients with CRF from both sexes were compared with (40) samples from healthy individuals as a control group. The results demonstrated significant elevation (p<0.05) in Oxt and IL-14 concentrations for patients with CRF compared to the control group. As for the subgroups, the statistical test showed a significant difference (p < 0.05) when comparing Oxt levels between the same sex in the two groups. While no significant difference was observed when comparing IL-14 in the same or the two groups. The parameters Oxt and IL-14 are necessary tools for predicting renal failure. Keywords: Oxytocin, Interleukin-14, Type 2 Diabetes Mellitus, Hemodialysis