Abstract
The fate of drug residues and their metabolites in the environment is relatively rarely investigated in the conditions of the Czech Republic, resulting in limited availability of scientific information. To demonstrate one example, we prepared a model study with medicated feedstuff containing oxytetracycline hydrochloride (OTC HCl), which was used in fish under normal conditions of use. The oxytetracycline (OTC) contents were determined in the sediments of the pond where the fish were treated. The ELISA method was used for OTC detection and the HPLC method was used for final quantification of OTC. The increasing contents of OTC in sediment depended on the repeated treatment and excretion of OTC by the fish. The concentration on day 59 after the last administration was 1516 μg kg-1 OTC in the sediment, which indicates a long-term persistence of the substance in the environment.
Highlights
Masaryk University Brno, Research Centre for Environmental Chemistry and Ecotoxicology, Faculty of Science, Brno, Czech Republic
Of about 13,500 tonnes of antibiotics administered in Europe every year, about 35% are used in veterinary medicine (Christensen et al 2006)
In fish farming, where 70 to 80% of antibiotics are administered in medicated pelleted feedstuffs, substances are released to the aquatic environment from urine, faeces and uneaten feed (Hektoen et al 1995)
Summary
Masaryk University Brno, Research Centre for Environmental Chemistry and Ecotoxicology, Faculty of Science, Brno, Czech Republic. The aim of the study presented here was to determine oxytetracycline concentrations in the bottom sediment in dependence on the time following the recommended administration of the registered veterinary drug Rupin Special gran. Samples of the sediment were collected from the feeding place and the pond inlet.
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