Abstract
Ionic Liquid-based Microwave-Assisted Extraction (Il-MAE) of Oxyresveratrol from Morus alba RootsMazaya Fadhila, Abdul Mun’im, Mahdi Jufri
Highlights
Cellular oxidative stress arising as a result of excessive free radicals or depletion of antioxidants is well recognized to cause cell damage (Golbidi et al, 2018)
Hydrogen peroxide induced the melanogenesis through tyrosinase activity-related cellular oxidants, whereas oxyresveratrol showed a potent antioxidant activity by dipheny l-1-picrylhydrazyl (DPPH) and ABTS assays
The generation of reactive oxygen species, especially H2O2, results in oxidative stress in epidermal melanocytes that promote the overproduction of melanin pigments (Panich et al, 2012)
Summary
Cellular oxidative stress arising as a result of excessive free radicals or depletion of antioxidants is well recognized to cause cell damage (Golbidi et al, 2018). Hydrogen peroxide induced the melanogenesis through tyrosinase activity-related cellular oxidants, whereas oxyresveratrol showed a potent antioxidant activity by DPPH and ABTS assays. At the concentrations of 10 and 12.5 μg/ml, oxyresveratrol significantly inhibited melanogenesis in B16 melanoma cells and suppressed tyrosinase activity and cellular oxidants.
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