Oxymatrine combined with thymosin alpha 1 in treatment of decompensated cirrhosis

Abstract

Objective To study the method and effect of oxymatrine combined with thymosin alpha -1 in the treatment of decompensated cirrhosis. Methods 100 patients with decompensated hepatitis C cirrhosis were selected from our hospital and randomly divided into a control group and a treatment group. The control group were treated with albumin and liver protection therapy and the treatment group with oxymatrine and thymosin alpha-1. The blood biochemical indexes, improvement effect of clinical symptoms, HCV-RNA (hepatitis C virus-RNA) level, child Pugh score, and adverse reactions were compared between these two groups. Results after 48 weeks’ treatment, the mean alanine aminotransferase was (45.3 ± 10.9) U / L, the average total bilirubin (30.1 ± 2.5) mol / L, the serum albumin level (36.7 ± 2.9) g / L, and the average PT (13.8 ± 2.9) s in the treatment group; after 24 and 48 weeks’ treatment, the above indicators were better in the treatment group than in the control group (P < 0.05). After 48 weeks’ treatment, the average HCV-RNA level was (3.01 + 0.28) loglOIU/ml in the treatment group, which was significantly better than that before the treatment and than that in the control group (P < 0.05). After the treatment, the disappearance rates of fatigue, abdominal distention, and ascites were 88%, 92%,and 92% in the treatment group. The symptom improvement rate was significantly higher in the treatment group than in the control group (P < 0.05). After 48 weeks’ treatment, the average child Pugh score was (5.5 ± 0.1) in the treatment group, which was better than that in the control group (P < 0.05). Both groups had good tolerance. No treatment-related upper gastrointestinal bleeding, hepatic encephalopathy, acute liver failure, renal function damage, etc. occurred in both groups. Conclusions Oxymatrine combined with thymosin alpha-1 in the treatment of decompensated cirrhosis patients can significantly inhibit the proliferation of virus, delay the progress of the disease, comprehensively improve the indicators, has few adverse reactions, and is safe and effective, so it is worth being generalized. Key words: Oxymatrine; Thymosin alpha 1; Decompensated liver cirrhosis; Antiviral effect