Abstract
The Bohr effect related to whole blood (Be) and erythrocyte pH (Bi) was determined over a wide oxygen saturation range at an almost constant 2,3-diphosphoglycerate concentration. In two different sets of experiments acidification was caused either by fixed acid (lactic acid) or by CO2. Fixed acid-induced Bohr coefficients can be approximated by a second-order function of O2 saturation with a maximum at mid-saturation range. CO2-inducedBe andBi values yield a third-order relationship with highest results at low O2 saturation. The ratioBi/Be with respect to fixed acid-acidification exhibits a positive correlation with oxygenation, whereas the corresponding ratio referring to CO2 does not. For this different behavior a possibly more pronounced diminution of the Haldane effect, i.e. oxygen-linked proton release, in the presence of fixed acid is discussed. The physiological importance of the magnitude of CO2-inducedBi values at low O2 saturation is emphasized.
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