Abstract
The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC50 values of 49.70 and 53.17 μM, respectively.
Highlights
IntroductionPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
The animal soft coral Sarcophyton convolutum was collected from the Egyptian Red
All cell lines were purchased from American Type Culture Collection (ATCC® ) and were maintained as monolayer culture in Dulbecco’s modified Eagle’s medium (DMEM) supplemented with
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Natural products and structural analogues are key for drug discovery, especially for pharmacotherapies for cancers and infectious diseases [1,2,3,4,5]. Such biologically active metabolites are characterized by scaffold diversity and structural complexity. Within Sarcophyton soft coral, isolated metabolites include cembrenoids [2,6,7,8,9], diterpene dimers [10,11], sesquiterpenes [12,13], ceramides [14], steroids [15,16], and prostaglandins [17,18].
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