Abstract

Efficient transport of oxygen is one of the main requirements in tissue engineering systems in order to avoid cell death in the inner tissueregions and support uniformtissueregener- ation. In this paper, we review approaches to de- sign of tissue engineering systems with adequate oxygen delivery for cultivation of cartilage and myocardium, two distinctly different tissue types with respect to the tissuestructure and oxygen re- quirements. Mathematical modeling was used to support experimental results and predict oxygen transport within the cultivated tissues and corre- late it to the cell response and tissue properties. Keyword: tissue engineering, oxygen trans- port, cartilage, myocardium, mathematical mod- eling

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