Oxygen supply by perfusion and diffusion in heterogeneous tissue models.

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Ample evidence for tissue perfusion inhomogeneity has been provided in resting and stimulated skeletal muscle preparations by microsphere embolization (Cerretelli et al., 1984; Iversen and Nicolaysen, 1989, 1990; Iversen et al., 1989; Marconi et al., 1988; Pendergast et al., 1985; Piiper et al., 1985), by inert gas washout (Grønlund et al., 1989; Piiper and Meyer, 1984), by local radioactive xenon clearance (Cerretelli et al., 1984), by observation of the variance of transit times, of the local tissue Po 2 heterogeneity and by other methods (cf. Piiper, 1985; Piiper, 1990). There is also morphometrical evidence for the irregularity of the capillary array in the myocardium (Turek and Rakusan, 1981; Hoofd et al., 1985; Rakusan et al., 1984) and in skeletal muscle (Egginton et al., 1988).KeywordsHomogeneous ModelRequirement RatioBlood Flow DistributionMammalian Skeletal MusclePerfusion HeterogeneityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.