Abstract
Activity of crystalline glyceraldehyde-phosphate-dehydrogenase was inhibited by incubation of the enzyme in the presence of 1 or 5 atmospheres of oxygen and catalytic amounts of copper or ferrous ions. Decrease in enzyme activity was associated with a disappearance of protein sulfhydryl groups. The experiments provide support for the hypothesis that oxidation of enzyme sulfhydryl groups is one possible mechanism of oxygen toxicity.
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