Abstract
Oxygen acts as a potent upstream signaling molecule to control a plethora of cell functions and cell fates. In three-dimensional (3D) tissues, the oxygen concentration is not uniformly distributed, but rather a gradient that depends on distance from oxygen-carrying blood vessels. During tissue regeneration, development or uncontrolled growth (i.e. tumor), restricted oxygen transport leads to severe hypoxic gradients. In these same tissues, the extracellular matrix (ECM) provides critical support for cell adhesion, proliferation, migration, and morphogenesis. In this talk I will present our recent efforts to study how hypoxic signaling induce a myriad of cellular and systemic adaptations. Examples will include interface along stem cell differentiation, vascular assembly and sarcoma metastasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
