Abstract
Varicose saphenous vein segments, segments of those veins with thrombophlebitis, and segments of normal veins obtained during operation on 23 patients were studied to define the pattern of pro-oxidative and antioxidative systems in these tissues. In segments of varicose veins (VV) the activity of superoxide dismutase (SOD) was significantly decreased as compared with normal veins: 7.8 ±2.9 vs 13.5 ±4.3 U/mg of protein (P < 0.05), but it was almost unchanged in the segments of W with thrombophlebitis. The activity of glutathione reductase (GSH-R) in all studied segments was similar and amounted to about 12.0 IU. The content of free sulfhydryl (SH) groups, the concentration of ascorbic acid, and thiobarbituric acid-reactive substances (TBA-RS) in segments of VV were significantly decreased by 40%, 48%, and 47%, respectively (P < 0.05) as compared with segments of normal veins. The values of ascorbic acid and TBA-RS in the segments of W with thrombophlebitis were increased by 13% and 16%, respectively, as compared with segments of normal veins. Decreased activities of SOD and reduced levels of free SH-groups and of ascorbic acid concentration in W may indicate impaired antioxidant mechanisms in this tissue.
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