Abstract
The study was performed to investigate possible alterations in oxygen consumption in an animal model with broad intestinal resection. Oxygen consumption and the thermal effect of a short meal were measured in rats subjected to short bowel syndrome. Four groups of rats were used. Group I was the control group, group II was sham operated, group III was submitted to 80% jejunum-ileum resection, and group IV was submitted to 80% jejunum-ileum resection with colon interposition. Ninety days after surgery, oxygen consumption was measured over a period of 6 h with the animals fasted overnight. The thermal effect of feeding was determined in another session of oxygen consumption measurement in animals fasted for 12 h. A 12-kcal meal was then introduced into the animal chamber and oxygen consumption was measured for a further 4 h. No differences in fasting oxygen consumption or in the thermal effect of the meal were detected among the groups studied. It is concluded that short bowel syndrome does not affect the overall energy expenditure of rats.
Highlights
Group I was the control group, group II was sham operated, group III was submitted to 80% jejunum-ileum resection, and group IV was submitted to 80% jejunum-ileum resection with colon interposition
The small intestine alone is responsible for almost the whole intestinal absorption and resection of more than 50% of its length may cause nutritional and metabolic abnormalities known as short bowel syndrome which leads to body weight loss, malabsorption, steatorrhea and acid diarrhea [1]
Since there is no information about the energy expenditure in individuals suffering from small bowel syndrome it may be relevant to study possible alterations in oxygen consumption in an animal model subjected to broad intestinal resection
Summary
The small intestine alone is responsible for almost the whole intestinal absorption and resection of more than 50% of its length may cause nutritional and metabolic abnormalities known as short bowel syndrome which leads to body weight loss, malabsorption, steatorrhea and acid diarrhea [1]. The study was performed to investigate possible alterations in oxygen consumption in an animal model with broad intestinal resection. Oxygen consumption and the thermal effect of a short meal were measured in rats subjected to short bowel syndrome.
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Schedule a callMore From: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
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