Abstract
Respiration of regenerating liver was compared with the rate of regeneration at varying intervals after removal of the left lateral and median lobes of the liver of rats. This subtotal hepatectomy was found to remove 66% of the total liver of rats in a comparable weight range; control animals were laparotomized, the liver was exposed for the same length of time, and the viscera were manipulated in an analogous manner. At 1, 2, 3, 4, 7 and 14 days postoperative, the rats were killed by exsanguination, the liver remnant was weighed and slices prepared for manometric studies in Ringer-phosphate-glucose medium. At 3 days, when growth was most rapid, liver respiration was increased 40%. By 14 days, when the liver had reached its calculated preoperative weight and growth had slowed considerably, respiration was 14% higher than controls. Hypothyroid rats, prepared by previous thyroidectomy, had a lower rate of liver regeneration after hepatectomy, but respiration, although at a lower level, showed comparable stimulation.
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