Abstract

AbstractA biochemical paradox that has been observed for many years is now becoming understood: O2, essential for the aerobic life forms, can be inappropriately metabolized, becoming toxic to an organism. Mammals derive most of their cellular adenosine triphosphate (ATP) from the controlled four-electron reduction of O2, to form H2O by the mitochondrial electron-transport system. Approximately 98% of all O2 consumed by cells enters the mitochondria, where it is reduced by a terminal oxidase, such as cytochrome oxidase. KeywordsOxygen ConsumptionXanthine OxidaseLipoxygenase ActivityClark ElectrodeIndicator CompoundThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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