Abstract
Background: By lowering the oxygen fraction of the reperfusate, the reactive oxygen-derived free radicals can be reduced thus facilitating myocardial recovery during weaning from cardiopulmonary bypass and after surgery. Materials & Methods: Thirty patients undergoing mitral valve replacement were randomly exposed to an oxygen fraction of 0.7 (hyperoxic, n = 15) or 0.5 (normoxic, n = 15) during reperfusion. Hemodynamic variables, number of patients requiring additional inotropes and who developed new arrhythmia, duration of ventilation and intensive care unit stay, arterial blood gas and renal function were measured. Results: The demographic data, duration of cardiopulmonary bypass, aortic cross clamp time, duration of mechanical ventilation, intensive care unit stay, additional inotropes, arrhythmia after reperfusion and renal function were similar in both groups. Arterial blood gas analysis was not significantly different, except for the low oxygen partial pressure in the normoxic group during reperfusion. With regard to hemodynamic variables, mean arterial pressure of the hyperoxic group was higher one hour after the cross clamp release. Hemodynamic variables were comparable in all other time periods. Conclusion: By reducing the oxygen concentration during reperfusion, the clinical outcomes in terms of inotropes usage, new arrhythmia after reperfusion, renal function, duration of ventilation and intensive care unit stay were not significantly altered.
Highlights
During cardiopulmonary bypass, the myocardium is damaged by ischemic injury and by reperfusion injury
The duration of cardiopulmonary bypass and aortic cross clamp were higher in normoxic group it was not significant
Additional inotropic requirement and new arrhythmia ater reperfusion was similar in both groups (Table 2)
Summary
The myocardium is damaged by ischemic injury and by reperfusion injury. By lowering the oxygen fraction of the reperfusate, the reactive oxygen-derived free radicals can be reduced facilitating myocardial recovery during weaning from cardiopulmonary bypass and after surgery. Results: The demographic data, duration of cardiopulmonary bypass, aortic cross clamp time, duration of mechanical ventilation, intensive care unit stay, additional inotropes, arrhythmia after reperfusion and renal function were similar in both groups. Cardiopulmonary bypass is commonly instituted in a hyperoxic fashion where the arterial oxygen tension is 300 to 400 mm of Hg. The overproduction of oxygenderived free radicals and cytosolic calcium are the major causes for ischemic-reperfusion myocardial injury. By lowering the oxygen fraction of the reperfusate, the reactive oxygen-derived free radicals which are the main causes of reperfusion myocardial injury can be reduced facilitating myocardial recovery during weaning from cardiopulmonary bypass and after surgery
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