Abstract
The sequence of erythropoietic events occurring during normal development of an embryo to an adult is a useful system for demonstrating cellular differentiation in relation to function. In mice there are two generations of red cells. The first, the primitive erythroid cells, originate in the blood islands of the yolk sac from about 8 days gestation and enter the circulation at 9 – 10 days gestation. These are large nucleated cells which continue dividing after release, and synthesize the three embryonic haemoglobins, EI (x2y2), EII (α2y2), and EIII (α2z2). The second generation of red cells, the definitive erythroid cells, are produced in the liver and enter the circulation from about 12 days gestation. These are non-nucleated and contain only adult haemoglobin (α2β2) (Fantoni et al., 1967).
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