Oxycodone intravenous for acute pain management in modified radical mastectomy

Abstract

Oxycodone hydrochloride is a semisynthetic opioid which extracted from the baine plant, with a similar analgesic potency compared with morphine. Although oxycodone was introduced in 1917, the global use of oxycodone in acute postoperative management became popular in the past decades. Oxycodone has a bioavailability up to twice from the bioavailability of morphine in the enteral route and shows more potency in visceral pain. Furthermore, oxycodone has better pharmacokinetics in the central nervous system than morphine and has less adverse effects. In this case series, we report the effects of analgesia, inflammatory markers, and adverse effects of continued intravenous oxycodone as acute pain management in patients who underwent a modified radical mastectomy.