Abstract
Diaqua(dipicolinato)oxovanadium (IV) ethanol solvate crystallizes in the triclinic space group P1. The complex was characterized by FTIR, elemental analysis, thermal gravimetric analysis, and solution visible spectral analysis. The complex alone cleaved DNA in the absence of hydrogen peroxide and its nucleolytic efficiency is greater than that of VOSO4. Its nucleolytic efficiency is affected by the choice of buffer used and pH. DNA cleavage can be inhibited by DMSO, NaN3 and catalase, implying involvement of ROS. An MTT assay, involving the lung cancer cell line PC9, gave IC50 values of 9.5 ?M and 16 ?M for the complex and VOSO4 respectively. For breast cancer cell line MCF-7, this complex is less cytotoxic, with an IC50 of 16 ?M.
Highlights
Vanadium(IV) and vanadium(V) inorganic salts and complexes have generated widespread interest due its insulin-mimetic property [Crans, et al, 2000, Sakurai, et al, 2002, Shechter, et al, 2003]
Evangelou reported that DNA cleavage in vivo and in vitro was shown to be among one of the different modes of action of these antitumor vanadium compounds
This paper presents the crystal structure of a diaquaoxovanadium(IV) ethanol solvate, abbreviated as VO(dipic), and both its nucleolytic and anticancer properties
Summary
Vanadium(IV) and vanadium(V) inorganic salts and complexes have generated widespread interest due its insulin-mimetic property [Crans, et al, 2000, Sakurai, et al, 2002, Shechter, et al, 2003]. In the search for a better and less toxic oral substitute for insulin in the treatment of both Type I and Type II diabetes, vanadium complexes of newer. The vanadium (IV) and vanadium (V) complexes of dipicolinic acid and derivatives have been found to be insulin-mimetic [Crans, et al, 2000, 2003]. Besides this insulin-mimetic property, some vanadium salts and complexes have been investigated for their antitumor behaviour and their possible development into a new class of non-platinum antitumor agents [Evangelou, 2002]. This paper presents the crystal structure of a diaqua (dipicolinato)oxovanadium(IV) ethanol solvate, abbreviated as VO(dipic), and both its nucleolytic and anticancer properties
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
