Oxovanadium (IV) complexes of 2-aryl/heteroaryl-3-hydroxy-4H-chromones: synthesis, spectral and thermal degradation studies

Abstract

The clinically active functionalized flavonols (2-aryl/heteroaryl-3-hydroxy-4H-chromones) (4a-l) have been synthesized from Algar–Flynn–Oyamada transformation of chalcones (1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-ones). Their oxovanadium metal complexes (5a-l) have been prepared and characterized by physical, spectral, thermal and analytical data. The functionalized flavonol acts as bidentate ligand and coordinates with vanadium metal atom through hydroxyl and carbonyl groups. The complexes have general formula [MOL2], where M = vanadium, O = oxygen and L = ligand. The chelation process reduces the polarity of metal ion by coordinating with ligands, which increase the lipophilic nature of the metals. This lipophilic nature of the metal enhanced its penetration through the lipoid layer of cell membrane of the micro-organism. This constitutes a new group of compounds that can be used as potential metal-derived drugs.