Abstract
1. Oxotremorine exerts an action on peripheral cholinoceptors in the anaesthetized rat. After the blockade of peripheral cholinoceptors with the quaternary atropine derivative, atropine methylbromide, oxotremorine produced a rise in arterial blood pressure and tachycardia.2. The rise in arterial pressure and tachycardia was absent in rats that had been pithed or had undergone high spinal cord transection.3. A non-quaternary atropine derivative antagonized these cardiovascular effects.4. Drugs which inhibit activity of the sympathetic nervous system antagonized the oxotremorine-induced hypertension and tachycardia.5. It is concluded that the rise in arterial pressure and tachycardia seen in the anaesthetized rat treated with a quaternary derivative of atropine is due to an action of oxotremorine on the central nervous system at a supraspinal level, resulting in an increase in activity of the efferent sympathetic nervous system.
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