Oxigênio-ozonioterapia na prática clínica humana: uma revisão integrativa de literatura

Abstract

The aim was to summarize the recent scientific evidence related to the practice of oxygen-ozone therapy in human clinical care. Integrative review with the inclusion of articles in Portuguese, English and Spanish, published between 2018 and 2021. Databases used: VHL; CINAHL; BASE; COCHRANE; PUBMED; and, WoS. The descriptors were chosen using the acronym PICo of the guiding question. For the development of the review, the recommendations of the Guideline Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) were followed and the level of evidence of the articles was evaluated according to the Oxford Centre. Included 24 articles whose research methods were: Case Reports (33.3%); Clinical Trials (33.3%); Systematic Reviews (12.5%); Scoping Review (4.2%); Case-control study (8%); Quasi-experimental study (4%); and, Case Series (4%). The main conditions treated with oxygen-ozone therapy were: osteoarticular diseases; COVID-19; infections; wounds; fibromyalgia. Yet, the process of assisted reproduction. The degree of recommendation of the analyzed studies, according to Oxford, were: 54.2%, Grade A; 12.5%, Grade B; and 33.3% Grade C. As an innovative integrative and complementary therapeutic approach, Oxygen-Ozone Therapy was identified as successfully applicable for the treatment of specific health situations in different scenarios.