Oxidovanadium Complexes for the Consumption of Alkylating Toxins (Eur. J. Inorg. Chem. 1/2009)

Abstract

AbstractThe cover picture shows oxidovanadium complexes transforming alkylating toxins into alcohols. Variation of the electron‐donating ability of the ligand was found to permit a degree of control over the reactivity with alkylating agents. Kinetic studies revealed a small range of kobsd. values for this series of K[VO2(salhyph(R)2)] complexes (R = –NO2, –H, –CH3, –OCH3) examined. These experiments were carried out with an ultimate goal of developing compounds to consume toxins and prevent DNA alkylation damage. Details are discussed in the Short Communication by J. J. Wilker et al on p. 33 ff.