Abstract
The realization of the reversible inter-conversion between NAD+ and NADH (Scheme 1) is a long-term challenge in biological and energy-related chemistry. Potential of Ru(edta) complexes mimicking oxidoreductase enzymes in the redox conversion of NAD coenzymes has been explored in the present work. The oxidation of NADH to NAD+ by [RuIII(edta)(pz)]- (edta4- = ethylenediaminetetraacetate; pz = pyrazine) has been studied spectrophotometrically and kinetically in aqueous solution at pH 7.0 (mes buffer) as a function of [NADH] and temperature. A working mechanism for the [RuIII(edta)(pz)]- complex mediated redox conversion of NAD coenzymes has been proposed. A mechanism in agreement with the kinetic data and activation parameters is presented.
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