Abstract
Introduction Oxidized regenerated cellulose is a relatively recent addition to the surgeon's armamentarium for hemostasis. Its hemostatic and absorbable qualities have been attested to by several authors in recent articles. 1-5 There have also been several articles describing its chemical nature, the mechanism of solubility in human tissues, and, finally, the methods by which it stops bleeding. 1,5 Briefly, it is a polyanhydroglucuronic acid manufactured from a substantially pure α-cellulose. 5 Its specific hemostatic property apparently depends upon the formation of a coagulum consisting of cellulose acid and hemoglobin, and it has been demonstrated to be readily soluble in alkaline solution. 5 It is our purpose to evaluate this hemostatic gauze experimentally with regard to the frequently trying problem of hepatic hemostasis and to comment on a few of our clinical experiences with this material to date. Methods and Procedures Adult, medium-sized mongrel dogs were used. All operations were done
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