Oxidized Low Density Lipoprotein in Patients with Kawasaki Disease

Abstract

Background: Recently, more and more studies have demonstrated that oxidized low density lipoprotein (ox-LDL) played a key role in the pathogenesis of adult coronary artery disease. This study was to investigate the ox-LDL and general lipoprotein profiles in patients with Kawasaki disease.Methods: Forty consecutive patients with Kawasaki disease who underwent cardiac catheterization were studied prospectively. We classified the patients into two groups: Group A consisted of 12 patients with coronary artery disease, coronary stenosis or aneurysm. Group B consisted of 28 patients with normal coronary angiography. Blood sample was tested for the levels of ox-LDL autoantibody, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG).Results: There were no significant differences between two groups in gender, age of onset of disease, TG, cholesterol, HDL-C, LDL-C, and TC/HDL. There was significantly higher level of ox-LDL in group A than that in group B (p=0.008).Conclusions: There is significantly higher level of ox-LDL in patients of Kawasaki disease with coronary artery disease. The role of Ox-LDL needs further studies.