Oxidized low density lipoprotein and paraoxonase activity in coronary artery disease

Abstract


 Background: High-density lipoprotein (HDL) has a reverse relation with incidence of coronary artery disease (CAD). Paraoxonase (PON) is an HDL associated enzyme responsible for antioxidant capacity of HDL. Oxidative modification of LDL results in formation of oxLDL. This can be reduced by Paraoxonase, which has anti-inflammatory and antioxidant function. Aim: To evaluate and compare the level of HDL, oxLDL and Paraoxonase (PON) activity in Coronary Artery Disease patients with controls. Effort was also made to correlate HDL with PON, also to correlate OxLDL with PON and HDL. Materials and Method: 60 clinically proven CAD patients within the age group of 35 to 70 were selected from OPD of Dr. Somervell Memorial CSI Medical College, Kerala. 60 controls within the same age group without any history of CAD was selected from subjects coming for Health Checkup. Results: HDL and PON were significantly lowered in CAD patients than in controls (P<0.05). OxLDL, Total Cholesterol, Triglyceride, LDL and VLDL were significantly higher in CAD patients than in controls (P<0.05). Correlation Analysis showed a positive correlation of HDL and PON. Statistically significant negative correlation was observed in case of oxLDL with PON and HDL.