Abstract
OBJECTIVE: Endometriosis, a disease with unknown etiology affects women of child-bearing age. It is characterized by the growth of endometrial tissue outside the uterus and is associated with chronic pelvic pain and infertility. The peritoneal fluid (PF) of women with endometriosis is a rich source for growth-promoting and inflammatory mediators. The PF also has measurable levels of pain-inducing prostaglandins (PGE2) and the endometriotic tissue is innervated with nociceptors. Non-steroidal anti-inflammatory drugs, though routinely used in the treatment of endometriosis is insufficient to relieve pain suggesting the presence of non-cycloxygenase generated pain molecules.
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